Results 111 to 120 of about 90,945 (315)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2013 Soiling of surfaces in historical buildings by deposition of particles is a common problem. Minimizing soiling is an important goal for conservation of structures and objects.
Mattsson, Magnus +2 more
core
Energy efficiency and HVAC systems in existing and historical buildings
, 2017 Refurbishment of existing and historical buildings is a priority in many European countries. Due to the need of developing a harmonized approach focusing on historical buildings, in 2014 AiCARR (Italian Association for air conditioning, heating ...
de Santoli L. +5 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Buildings, Main Street, Miller SD, Hand County
3 x 5 postcard, car and people downtown, one of the buildings is the Miller PressTowns Madison - Miller P22 Poster board Miller P22 [stamp] Property of South Dakota State Historical Society Pierre, South Dakota. [stamp] Give photo credit to: South Dakota
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Indiana State Library and Historical Building
, 1934 View of the Indiana State Library and Historical Building located on the corner of Senate and Ohio Streets. Cars are parked around the building.
W. H. Bass Photo Company
core