Results 101 to 110 of about 90,945 (315)

Pilot Survey On The Conservation Of Historical Buildings In Malaysia

open access: yes
Historic buildings basically represents the single most visible aspect of our past history and culture. Like most other countries in the world, Malaysia has a rich legacy of historic buildings with outstanding craftsmanship and architecture quality. They
Ahmad, A_Ghafar   +2 more
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Boston & Newhouse Buildings p.1

open access: yes
Boston and Newhouse buildings with insert of Samuel Newhouse, financer of the construction of the ...

core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Historical Building

open access: yesProceedings of the 4th Sriwijaya University Learning and Education International Conference (SULE-IC 2020), 2020
Aulia Novemy Dhita   +2 more
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Valuation of historical buildings

open access: yesOvidius University Annals of Constanta - Series Civil Engineering
Abstract The present work brings together various intervention solutions on similar buildings in the city of Oradea, dating from the same period: around the 1900s. The buildings of the study are not historical monument buildings, but in the General Urban Plan of the city of Oradea, they are symbolized as buildings of historical value.
Ioana Francesca Hanga-Farcaș   +5 more
openaire   +1 more source

Boston & Newhouse Buildings p.6

open access: yes
Boston and Newhouse buildings under ...

core  

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