Results 81 to 90 of about 90,945 (315)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Research on Identification, Evaluation, and Digitization of Historical Buildings Based on Deep Learning Algorithms: A Case Study of Quanzhou World Cultural Heritage Site

Buildings
Historical buildings have important historical and social value, but they are generally difficult to identify, complicated to evaluate, and insufficiently addressed in digitization research.
Siqi Wang, Jiahao Zhang, Aung Nyan Tun, Kyi Sein   +3 more
doaj   +1 more source

An integrated process for rehabilitating historical buildings

, 2014
This paper reviews the energy upgrading of historical buildings and its relationship with structural rehabilitation. Regarding the structural aspects, over the last 20 years a correct culture of architectonic conservation has revealed the inadequacy of ...
D'Agostino S, D'Ambrosio Alfano FR, BELLIA, LAURA   +2 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Numerical simulation and diagnosis geotechnical parameters of historical buildings in Najran City, Kingdom of Saudi Arabia. [PDF]

Sci Rep, 2023
Abdullah GMS, El-Aal AA, Radwan AE, Al-Awah H.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of Coal Mining on Historical Buildings: Case Study in Shanxi. [PDF]

Int J Environ Res Public Health, 2023
Sun Y, Zhu S, Peng Z, Yang C, Zhou B, Wang X, Zhao Y.   +6 more
europepmc   +1 more source

Heat Accounting in Historical Buildings

, 2014
Modern devices for thermal energy measurement and accounting are rarely available in historical buildings, despite energy consumptions are not negligible.
RICCIO, GIUSEPPE, Celenza, Luca, D’Alessio, Raffaele, L. Celenza, M. Dell'Isola, R. D'Alessio, Ficco, Giorgio, Dell’Isola, Marco, G. Ficco, PALELLA, BORIS IGOR   +9 more
core  

Historical Building Energy Retrofit Focusing on the Whole Life Cycle Assessment—A Systematic Literature Review

Climate change is becoming one of humanity's major concerns. Remarkable steps are being implemented to reduce global emissions in all economic sectors, including the built environment.
Obead, Rania, Lina Khaddour, Bernardino D’Amico, D'Amico, Bernardino, Rania Obead, Khaddour, Lina   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source