Results 71 to 80 of about 90,945 (315)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Operational modal analysis method application and seismic performance evaluation for an iconic historical building constructed with different construction materials: Historical Elazığ Government Office (Türkiye)

Case Studies in Construction Materials
Historical buildings have a very important place for societies in terms of culture. For this reason, it is necessary to protect these buildings and transfer them to future generations.
Musa Yetkin
doaj   +1 more source

Historical buildings retrofit : the city hall of the city of Motta di Livenza (TV) [PDF]

, 2017
Issues related to energy saving, environmental sustainability and safety in case of seismic events are more and more the focus of attention of public opinion and the various actors of the construction sector.
Dalla Mora, Tiziano, Tiziano Dalla Mora, Alessandro Righi, Righi, Alessandro, Peron, Fabio, Fabio Peron, Romagnoni, Piercarlo, Piercarlo Romagnoni   +7 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation on Accessibility in Historical Environments in Turkey: Ankara Ulus Environment Example

Iconarp International Journal of Architecture and Planning
Historical environments bear traces of the past and have cultural and historical importance. These places are essential to respect the past, understand history, and preserve cultural heritage.
Şule Nur Altın, Hatice Elmas, Can Güngör   +2 more
doaj   +1 more source

Analyzing the Meaning in the Historical and Contemporary Architecture of Semnan, Focusing on the Phenomenological Views of Norberg-Schults [PDF]

توسعه پایدار شهری
The issue of meaning is one of the discussed components in phenomenology in architecture. Understanding the meaning of the architectural work in the contemporary period compared to the past is something that can be studied.
Seyed Mahyar Hashemi Hezaveh, Faramarz Hassan Pour, Saeed Kamyabi   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Historic Buildings and Rehabilitation Expenditures: A Panel Data Approach [PDF]

This paper examines the relationship between the characteristics of buildings and their assessed value in a historic area in Winnipeg, Manitoba Canada.
Robert Fenton, Joseph Warbanski, Philippe Cyrenne   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Materials and techniques of Art Nouveau architecture in Italy and Portugal: a first insight for an European route to consistent restoration

, 2009
The results of the investigations on building materials and techniques of Casa Major Pessoa, a typical Art Nouveau construction in Aveiro (Portugal), and two coeval Art Nouveau buildings in Bologna (Italy) are presented as a methodological contribution
Sandrolini, F., Dell’Acqua, A. C., Varum, H., DELL'ACQUA, ADOLFO CESARE, SANDROLINI, FRANCO, Franzoni, E., H. Varum, FRANZONI, ELISA   +7 more
core