Results 61 to 70 of about 90,945 (315)

Redesign of a Rural Building in a Heritage Site in Italy: Towards the Net Zero Energy Target

Buildings, 2017
In order to achieve the ambitious objective of decarbonising the economy, it is mandatory, especially in Europe and in Italy, to include the retrofitting of existing buildings.
Maurizio Cellura, Giuseppina Ciulla, Francesco Guarino, Sonia Longo   +3 more
doaj   +1 more source

The constructability of Cheops Pyramid

Results in Engineering, 2020
The aim of this paper is to forecast the methodology by which Cheops Pyramid as a historic building was built, based on notions of modular patterns discovered within the following planar illustrations, starting at the apex and descending to its grand ...
Fouad Ghoussayni, Amer Ali, Ali Bayyati, Imad Dagher, Ismail Bayyati   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Historical buildings in South Africa

Contree
No abstract available.
G-M. van der Waal,
doaj   +1 more source

The Policies and Process of Preserving the Historical and Heritage Buildings in Dubai City: Case Study of Historical District

ARCHive-SR, 2019
Preserving historical buildings is considered of one of the major priorities in many cities in both developed and developing countries. Dubai is one of the major world cities that is experiencing rapid architectural transformations, thus the Dubai ...
Mai Alhasawi
doaj   +1 more source

Examination of Transformation in Historical Buildings within the Context of Worship Buildings

Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü, 2022
Historical buildings are social richness that brings the cultural, social and economic characteristics of the period. Historical places of worship are important places that are symbols of cities. Changing conditions over time cause the original functions
Sevim ATEŞ CAN, Şükran KARABACAK
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source