Results 51 to 60 of about 609,319 (304)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
[Review of] St. Clair Drake. Black Folk Here and There , vol. I [PDF]
, 1992 St. Clair Drake, the recently deceased anthropologist, has written an elaborate summary essay on the black experience as it relates to the continent of Africa.
Bracy, Bamidele J., Daniels, Jean E.
core +1 more source
This Is Not a Myeloproliferative Neoplasm…
Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Biographical Stages and Information Sources in the Formation of Historical Consciousness
Historická sociologie, 2020 The study inquires into the process of formation of historical consciousness among the population of the Czech Republic. The process is examined in terms of biographical stages and information sources. First, the study draws upon the concept of sensitive
Tomáš Karger +2 more
doaj +1 more source
Affective neuroscience, emotional regulation, and international relations [PDF]
, 2019 International relations (IR) has witnessed an emerging interest in neuroscience, particularly for its relevance to a now widespread scholarship on emotions.
Gammon, Earl
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Historical Analogies and Historical Consciousness: User-Generated History Lessons on TikTok
, 2022 As a major social media platform, TikTok also serves as a means for communicating about the past. Analyzing TikTok videos that feature the hashtags #historytiktok, #historymemes, and #historylesson, this chapter shows how TikTok’s platform affordances stimulate drawing analogies between present and past. Because TikToks are multimodal and allow for the
openaire +1 more source
The Role of the Church In Making Bio-Medical Decisions [PDF]
, 1976 Following is the text of an address deliuered by Bishop Dingman at the joint meeting of NFCPG and the National Association of Catholic Chaplains in September, 1975, in Washington, D.C. The author has been Bishop of Des Moines since 1968. In this article,
Dingman, Maurice J.
core +1 more source