Results 91 to 100 of about 2,005,241 (310)

Historical Traceability, Diverse Development, and Spatial Construction of Religious Culture in Macau

Religions
This study delves into the profound impact and significance of religious culture on the urban spatial configuration and local cultural essence of Macau amidst contemporary societal transformations.
Jianqiang Yin, Mengyan Jia
doaj   +1 more source

„Jen je škoda, že víme, jak to s Husem dopadlo.“ Šestisté výročí upálení Jana Husa v české vzpomínkové kultuře || "It's a shame we know what happened to Hus." The six hundred years' anniversary of the death of Jan Hus in the Czech memory culture [PDF]

Historie - Otázky - Problémy, 2018
The text explores the portrayal of Jan Hus in the context of the 600th anniversary of his death, which was commemorated in the year 2015. The author analyses different media used for commemoration of Jan Hus from the perspective of Memory Studies.
Kateřina Sixtová
doaj  

Pedagogies of Race: The Politics of Whiteness in an African American Studies Course [PDF]

, 2011
This paper evaluates students\u27 arguments for a color-blind society to avoid discussions related to the continued existence of racism in USA culture.
Jones, Regina V.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Historical, Jurisprudential, and Empirical Wisdom of Parental Responsibility Laws [PDF]

, 2012
The parent-child relationship is woven deep within historical and contemporary culture, but strong retributive ideals have led to blaming parents because of their presumed vicarious role in juvenile crime.
Brank, Eve M., Scott, Leroy
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Almirall Project: a portal of 19 th century culture and thinking [PDF]

, 2011
The Ateneu Barcelonès is a civil, private cultural association that has been a part of Spanish society and culture since 1860, having been founded with the aim of promoting dialogue and disseminating knowledge about the country's artistic, historical and
Alcaraz-Martínez, Rubén, Burguillos-Martínez, Ferran, Casas-Rivas, Pablo, Montes, Sergi, Vicente-Hernández, Lluís   +4 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

John Florio and Shakespeare: Life and Language [PDF]

, 2015
Investigations into the link between Shakespeare and John Florio stretch back to the mid eighteenth century when, in his edition of the plays (1747), William Warburton suggested that “by Holofernes is designed a particular character, a pedant and ...
Montini, Donatella
core