Results 111 to 120 of about 2,021,431 (308)
Anthony Trollope Competition [PDF]
, 2017 Essays are invited on the topic of Trollope and His World. Submissions may include essays focusing exclusively on the works of Anthony Trollope; comparative essays on Trollope and other writers; essays examining Trollope\u27s work and career in the ...
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
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The February JournalThis article investigates the methodological implications of playing as historical actors within immersive virtual reality (VR) environments. Drawing on a PhD project examining over 20 history-related VR experiences, it combines phenomenological ...
Roman Smirnov
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Individual and Cultural Historical Development
In this autobiography I describe how I became - via Teachers College (TC) -- a developmental psychologist. At the TC I was stimulated by a teacher to read and study scientific works on psychology. I was so enthusiastic about the then leading scholars of Dutch psychology that I decided to move to Groningen University to study psychology.
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Indigenous society and immigrants : tourism and retailing in Lijiang, China, a World Heritage city. [PDF]
, 2003 This paper examines the present state of commercial use of historical buildings, details of business categories, and descriptions of items on sale in the shops in the old town of Lijiang, China in order to investigate the problems of cultural-tourism ...
Yamamura, Takayoshi
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
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