Results 131 to 140 of about 2,021,431 (308)

Victorian Influence on \u3cem\u3eBeauty and the Beast\u3c/em\u3e [PDF]

, 2013
This essay examines a unique publication of the well-known Beauty and the Beast fairy tale. W.B. Conkey Company’s adaptation of Beauty and the Beast demonstrates the influence of Victorian culture on children’s literature (1897).
Stone, Elizabeth
core   +1 more source

Influence of geography on language competition

, 2008
Competition between languages or cultural traits diffusing in the same geographical area is studied combining the language competition model of Abrams and Strogatz and a human dispersal model on an inhomogeneous substrate.
Abrams, Ammerman, Baronchelli, Baronchelli, Bouchaud, Castelló, Castelló, Davison, Els Heinsalu, Hadzibeganovic, Ke, Lipowski, Lomolino, Loreto, Marco Patriarca, Martino, Minett, Mira, Murray, Nichols, Nowak, Patriarca, Pinasco, Press, Schulze, Schulze, Schulze, Stauffer, Stauffer, Steels, Wang, Wichmann   +31 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Historical consciousness as a factor of demyfologizing historical culture: philosophical and methodological aspect

Studia Humanitatis, 2016
The article analyses the philosophical and methodological problems of studying historical consciousness as a factor of demythologizing historical culture.
Ivanov Andrei Gennadiyevich, Linchenko Andrei Aleksandrovich   +1 more
doaj  

Mighty nation states and fragile international body: the German-Polish minority policy of the League of Nations as an early experiment in global governance [PDF]

, 2012
Globalization scholars generally acknowledge the United Nations as a key transnational actor that helps to regulate the globalized world by means of an institutionalized network of norms and agreements.
Delcour, Chloë
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Incongruent Amalgamation: John Stuart Mill\u27s Utilitarianism on Naturalism [PDF]

, 2015
John Stuart Mill\u27s utilitarian principle of the greatest happiness for the greatest number, often surfaces in cultural debates in the contemporary West over the extent and foundations of moral duties.
Robinson, Jeffrey M
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Harnessing Intelligent GISs for Educational Innovation: A Bibliometric Analysis of Real-Time Data Models

Education Sciences
This study explores the potential of Intelligent Geographic Information Systems (GISs) in advancing educational practices through the integration of real-time data models.
Eloy López-Meneses, Irene-Magdalena Palomero-Ilardia, Noelia Pelícano-Piris, María-Belén Morales-Cevallos   +3 more
doaj   +1 more source