Results 91 to 100 of about 2,021,431 (308)

Theorica et Practica: Historical Epistemology and the Re-Visioning of Thirteenth and Fourteenth-Century Medicine [PDF]

open access: yes, 2011
Positivist medical historians, guided by the savoir of modern western biomedicine, have long depicted medieval medicine as an aberration along the continuum of scientific and medical progress.
Gardenour, Brenda S.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

John Florio and Shakespeare: Life and Language [PDF]

open access: yes, 2015
Investigations into the link between Shakespeare and John Florio stretch back to the mid eighteenth century when, in his edition of the plays (1747), William Warburton suggested that “by Holofernes is designed a particular character, a pedant and ...
Montini, Donatella
core  

Evolution of Cultural Traits Occurs at Similar Relative Rates in Different World Regions [PDF]

open access: yes, 2014
A fundamental issue in understanding human diversity is whether or not there are regular patterns and processes involved in cultural change. Theoretical and mathematical models of cultural evolution have been developed and are increasingly being used and
Currie, TE, Mace, R
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Mummification – An historical and cultural overview

open access: yesJournal of Forensic and Legal Medicine
Review was undertaken of historical mummifications which has shown that this process has occurred accidently and deliberately in many cultures globally for millennia in a wide variety of environments. Although Egypt is considered the major source of mummified material, mummification has occurred in Europe, Africa, Asia, Oceania, Greenland and the ...
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Narratywizowanie przeszłości w cyfrowym ego-dokumencie na przykładzie gry autobiograficznej Cosmic Top Secret

open access: yesImages
The article addresses the problem of narrativizing the past in a digital ego-documentary using the example of the game Cosmic Top Secret (Klassefilm, 2018), directed by Trine Laier.
Marcin Pigulak
doaj   +1 more source

The historical evolution of accounting in China: the effects of culture. [PDF]

open access: yes
Muchos estudios recientes han afirmado que China integra en su sistema contable sus reglas tradicionales, sus intereses culturales y su estilo de vida. La “cultura” sería el punto dominante en su sistema contable.
Ayhan, Sinan, Solas, Cigdem
core  

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