Results 71 to 80 of about 7,848,834 (290)

Analysis of infections among patients with historical culture positive for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae: Is ESBL-targeted therapy always needed? [PDF]

Antimicrob Steward Healthc Epidemiol, 2023
Stone TJ, DeWitt M, Johnson JW, Beardsley JR, Munawar I, Palavecino E, Luther VP, Ohl CA, Williamson JC.   +8 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Kansas State Historical Society Annual Report, 2013

, 2013
Covers Fiscal Year 2013 The Kansas State Historical Society, Inc., doing business as the Kansas Historical Foundation, is an IRS determined 501(c)(3) non-profit and serves as the fund raising, fund management, membership, and retail organization for the ...
Kansas State Historical Society
core   +1 more source

Ontological analysis and disease statistics of wooden coffin paintings from the Qinghai Tibetan Medicine Culture Museum, China

Heritage Science
The 35 wooden coffin paintings from the Tubo period of the Tang Dynasty, housed in the collection of Qinghai Tibetan Medicine Cultural Museum, are valuable materials for studying Tubo culture.
Yanli Li, Yuyao Ruan, Cailuotai, Suonanji, Panpan Liu, Yuhu Li, Huiping Xing   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The influence of transmedia and extra-academic narratives on the formation of the historical culture of high school students

Frontiers in Education
This paper concerns with the importance of traditional and extra-academic sources of knowledge in the configuration of historical culture of Spanish adolescents.
Pablo Muñoz-Muñoz, Jorge Ortuno-Molina, Sebastian Molina-Puche   +2 more
doaj   +1 more source

Mummification – An historical and cultural overview

Journal of Forensic and Legal Medicine
Review was undertaken of historical mummifications which has shown that this process has occurred accidently and deliberately in many cultures globally for millennia in a wide variety of environments. Although Egypt is considered the major source of mummified material, mummification has occurred in Europe, Africa, Asia, Oceania, Greenland and the ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Historical Traceability, Diverse Development, and Spatial Construction of Religious Culture in Macau

Religions
This study delves into the profound impact and significance of religious culture on the urban spatial configuration and local cultural essence of Macau amidst contemporary societal transformations.
Jianqiang Yin, Mengyan Jia
doaj   +1 more source