Results 51 to 60 of about 131,188 (265)
Atentát na Heydricha ve filmu Anthropoid. Globální a lokální recepce minulosti || Heydrich's assassination in film. Global and local reception of the past [PDF]
Historie - Otázky - Problémy, 2018 Taking an example of an analysis of viewers’ comments on the film Anthropoid (2016, directed by Sean Ellis), on the local Czech portal csfd.cz and on the portal IMDB.com, opened to the global viewing community, shows some differences in the reception of ...
Jaroslav Pinkas
doaj
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Clio y Asociados, 2017 These paper aims discuss the relationship between historical knowledge and the political positioning of young people from the high school, between 15 and 18 years old. For do this, a quantitative data collection method was
Matheus Mendanha Cruz
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Museum and Historical Culture: How is Jewish History Included in the Museum Narrative of Lithuania? [PDF]
Revista Română pentru Studii Baltice şi Nordice, 2020 The aim of this article is to reveal the dynamics of the museum narrative of Jewish history in the contexts of Lithuanian historical culture in the period 1990–2020.
Rūta Šermukšnytė
doaj
Middle Paleolithic Site Sukhaya Mechёtka: the Renewal of Complex Investigations
Нижневолжский археологический вестник, 2020 The Sukhaya Mechёtka site, located on the northern outskirts of Volgograd, has attracted the attention of Paleolithic researchers since its discovery in 1951 by geologists A.I.Koptev and M.N. Grishchenko. The materials of the site - a collection of stone
Aleksander K. Otcherednoy +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Analysis of infections among patients with historical culture positive for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae: Is ESBL-targeted therapy always needed? [PDF]
Antimicrob Steward Healthc Epidemiol, 2023 Stone TJ +8 more
europepmc +1 more source