Results 121 to 130 of about 2,002,135 (290)
Yantu gongcheng xuebaoTo explore the development process of desiccation cracking in clay soil, the desiccation cracking deterioration on the surface of the archaeological site in sacrifice area of Sanxingdui Ruins site is taken as the research object.
ZHAO Fan 1, YAO Xue 2, HU Rui 1, LI Sifan 1, LI Junhao 1
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Anthony Trollope Competition [PDF]
, 2017 Essays are invited on the topic of Trollope and His World. Submissions may include essays focusing exclusively on the works of Anthony Trollope; comparative essays on Trollope and other writers; essays examining Trollope\u27s work and career in the ...
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Studia Humanitatis, 2016 The article analyses the philosophical and methodological problems of studying historical consciousness as a factor of demythologizing historical culture.
Ivanov Andrei Gennadiyevich +1 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Gender and Empowerment: Contemporary Lakota Women of Rosebud [PDF]
, 2004 Western-European stereotypes still permeate Plains Indian culture suggesting that women were passive and subjugated while men were dominant warriors.
Mello, Christina G.
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Education SciencesThis study explores the potential of Intelligent Geographic Information Systems (GISs) in advancing educational practices through the integration of real-time data models.
Eloy López-Meneses +3 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source