Results 111 to 120 of about 2,221,083 (311)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
, 2014 Strongly anticipatory systems-that is, systems which use models of themselves for their further development-and which additionally may be able to run hyperincursive routines-that is, develop only with reference to their future states-cannot exist in res ...
Leydesdorff, Loet
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Trust Development in Research with Indigenous Communities in the United States [PDF]
, 2014 A historical backdrop of oppression and exploitation has set the stage for distrust in research relationships with many indigenous communities. Although distrust poses a barrier to conducting research with indigenous communities, it also provides a ...
Burnette, Catherine E., Sanders, Sara
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Is India's economic growth leaving the poor behind? [PDF]
There has been much debate about how much India's poor have shared in the economic growth unleashed by economic reforms in the 1990s. The authors argue that India has probably maintained its 1980s rate of poverty reduction in the 1990s. However, there is
Datt, Gaurav, Ravallion, Martin
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Some Actual Aspects of the Methodology of Jurisprudence in the Newly Independent States of Eurasia
Управленческое консультирование, 2018 The article highlights relevant aspects of research methodology in the field of legal science of the newly independent states of Eurasia. The author draws attention to the need to study the historical experience of the development of the theory of state ...
Narman Myrzachmetovich Sadykov
doaj
"Quantization is a mystery" [PDF]
, 2012 Expository notes which combine a historical survey of the development of quantum physics with a review of selected mathematical topics in quantization theory (addressed to students that are not complete novices in quantum mechanics). After recalling in
Todorov, Ivan
core +1 more source