Results 121 to 130 of about 2,231,122 (308)
Some Actual Aspects of the Methodology of Jurisprudence in the Newly Independent States of Eurasia
Управленческое консультирование, 2018 The article highlights relevant aspects of research methodology in the field of legal science of the newly independent states of Eurasia. The author draws attention to the need to study the historical experience of the development of the theory of state ...
Narman Myrzachmetovich Sadykov
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Meaning of World History and The Evolution of States of The Ancient World
Теоретическая и прикладная юриспруденцияIntroduction. The article attempts to examine the main patterns and driving forces of state evolution using specific historical material from the evolution of states in the Ancient World.
N. V. Razuvaev
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Rentier States and Geography in Mexico's Development [PDF]
This paper provides a long-term historical and econometric account of the way in which geography has shaped development in the Mexican states. The emphasis is placed on the way in which the natural geography is reinforced by political decisions, which ...
Alberto Díaz Cayeros, Roberto Blum
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Masterclass: international law and constitutional development in 19th century Europe (Part II) [PDF]
, 2015 1. Today, Hungary is a small Central-Eastern-European country making headlines with its domestic political and constitutional controversies. Yet, throughout its 1000-year history, this country had many struggles and developments, which, when put into a ...
Beke-Martos, Judit
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The European Social Model and eastern enlargement [PDF]
"The European Social Model (ESM) is increasingly becoming a model of integration policy. The idea is based on a combination of economic efficiency, in the sense of high productivity, competition and economic growth, and a high level of employment on the ...
Buttler, Friedrich +2 more
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