Results 151 to 160 of about 2,221,083 (311)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Historical Development of Environment Protection Laws in the State of Qatar
مجلة الاجتهاد للدراسات القانونية والاقتصادية, 2020 Qatar is one of the countries which pay considerable attention to environment, and thus enacted several legislations and laws to safeguard environment and life from any sort of pollution and harm. In mid-70s of the twentieth-century, State of Qatar established the Supreme Council for Environment and Nature Reserves (SCENR) to set up general policies on
openaire +1 more source
Musical Influence on Apartheid and the Civil Rights Movement
, 2014 Black South Africans and African Americans not only share similar identities, but also share similar historical struggles. Apartheid and the Civil Rights Movement were two movements on two separate continents in which black South Africans and African ...
Power, Katherine D.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Achieving equity to fully realise the pandemic agreement. [PDF]
BMJ Glob HealthSilva DS, Pahlman K, Smith MJ.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Constructing national identity in public health crises: a comparative DHA study of China and the United States (2003-2023). [PDF]
Front Public HealthWu W.
europepmc +1 more source
STATE AND PROSPECTS OF HISTORICAL CONSCIOUSNESS DEVELOPMENT IN MODERN RUSSIA
, 2020 The article considers the significance of the historical education and upbringing in the establishment of the historical consciousness of Russian young people. The authors show the most effective trends of its formation in the Russian Federation. There are analysed the key principles of the historical education in schools and institutes of the country ...
openaire +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source