Results 151 to 160 of about 349,501 (319)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Posicionamento político, conhecimento histórico e pensamento utópico: Uma análise com dados quantitativos de jovens dos Campos Gerais/Pr - 2017

Araucaria, 2019
The text hereinafter have with theoretical basis the german tendency of Historical of Didatic, primarily the proposals of Rüsen. The effort made was to relate concepts that field os study with data collected of empirically through of questionnaires ...
Matheus Mendanha Cruz
doaj  

Analysis of the stakes of the Xianyang Ancient Ferry Site, Shaanxi, China

Heritage Science
Historical records indicate that Xianyang Ancient Ferry Site, dating back over three millennia to the late Shang Dynasty, has been an important transportation hub in ancient times.
Gele Teri, Peng Fu, Kezhu Han, Dan Huang, Yanli Li, Yujia Luo, Huiping Xing, Yuhu Li   +7 more
doaj   +1 more source

"Some reckoning of gains is made" : a historical inquiry into assessment in child-centred curricula [PDF]

, 2015
Child/learner-centred curricular reform has struggled to be an enduring force in Alberta since its first appearance in the1936 Enterprise curriculum. Through researching assessment theory, policy, and practice in Alberta’s Enterprise curricula from 1936 ...
Rempel, James
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Ontological analysis and disease statistics of wooden coffin paintings from the Qinghai Tibetan Medicine Culture Museum, China

Heritage Science
The 35 wooden coffin paintings from the Tubo period of the Tang Dynasty, housed in the collection of Qinghai Tibetan Medicine Cultural Museum, are valuable materials for studying Tubo culture.
Yanli Li, Yuyao Ruan, Cailuotai, Suonanji, Panpan Liu, Yuhu Li, Huiping Xing   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Examining teacher education through cultural-historical activity theory

Cultural-historical activity theory (CHAT) is an approach that can be used to analyse human interactions and relationships within particular social contexts.
Wilson, Viv
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source