Results 51 to 60 of about 4,140,050 (256)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

The Criticism of Materialism in Late Ottoman’s New Science of Kalām

open access: yesULUM, 2019
Materialism, which reduces the whole of existence as simply matter and its interactions, and respectively ignores the intervention of a divine being into the universe; it is often traced back to a time when philosophy was born. However, when we study the
Mehmet Bulğen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Lyubov Axelrod on Kant: Reflections on Marxist Discussions of the 1920s and 1930s in the USSR

open access: yesКантовский сборник
The authors attempt to look back on discussions of Marxist philosophy and historical materialism in this country without censoring, obfuscating, or simplifying issues in order to assess the prospects of their development.
Tatiana G. Shchedrina   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Hegemony and Sustainability. A Call for Historical Materialism

open access: yesSocietàMutamentoPolitica: Rivista Italiana di Sociologia
Social scientists have been critical about sustainability from its appearance. However, as the literature on post-politics highlight, they have failed to address why our society endures in unsustainability in what some authors call the post-ecological ...
Sergio D'Agata
doaj   +1 more source

Review essay on David Laibman, Deep History: A Study in Social Evolution and Human Potential [PDF]

open access: yesThe Journal of Philosophical Economics, 2011
While historical materialism and evolutionism provide similar explanations and ideas regarding the cause of long-term social change, the two theories are rarely used in conjunction with one another. In Deep History,the author David Laibman addresses some
Altug Yalcintas
doaj  

Historical Materialism and Progress

open access: yesRetrospektive
The paper addresses the concept of progress through an examination of different paradigms in the natural and social sciences. By considering how progress relates to various theoretical frameworks, it analyzes the distinction between teleology and evolution; scientific attempts to reconstruct a theory of history; definitions of capitalism that imply ...
openaire   +2 more sources

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