Results 61 to 70 of about 4,140,050 (256)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Historical Materialism Conference Poster 2019
Historical Materialism Conference Poster 2019 with "Construct 30. Morris & Co.
Mabb, David
core +7 more sources
Pepijn Brandon, War, Capital and the Dutch State (1588-1795).
BMGN: Low Countries Historical Review, 2017 Pepijn Brandon, War, Capital and the Dutch State (1588-1795) (Dissertatie Universiteit van Amsterdam 2013; Historical Materialism Book Series 101, Leiden: Brill, 2015, 447 pp., ill., isbn 978 900 422 814 6).
Oscar Gelderblom
doaj +1 more source
HoST, 2020 This contribution interprets the intertwined issues of science, epistemology, society, and politics in Gramsci’s Prison Notebooks as a culturalist approach to science that does not renounce objectivity.
Omodeo Pietro Daniel
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Chinese organic materialism and modern science studies: Rethinking Joseph Needham’s legacy
Cultures of Science, 2020 Historian of science Joseph Needham argued in various papers and books that the philosophy of organic materialism that informed classical Chinese science not only nurtured Chinese discoveries in areas such as magnetic studies, but also obstructed the ...
Arun Bala
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source