Results 131 to 140 of about 1,186,802 (304)
Resurrecting Silent Histories: A Journey through the Historical Novels of Kurdish Author Jan Dost
Orientalia SuecanaThis article explores the historical novels of Kurdish author Jan Dost, highlighting their role in resurrecting and preserving the silent histories of the Kurdish people.
Hashem Ahmadzadeh
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Child Quantity-Quality Trade-Off During the Industrial Revolution in England [PDF]
We take Gary Becker's child quantity-quality trade-off hypothesis to the historical record, investigating the causal link from family size to the literacy status of offspring using data from Anglican parish registers, c. 1700-1830.
Jacob Weisdorf, Marc Klemp
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
La Historia en clave emocional en Inés y la alegría de Almudena Grandes
Studia Romanica Posnaniensia, 2017 Isabel Burdiel (2015) points out that since the realism of the 19th century – the genre which inspired Almudena Grandes for her ambitious narrative project Episodios de una guerra interminable – there has been a constant exchange of narrative goals ...
Aránzazu Calderón Puerta
doaj
Scenarios of Nostalgia. Public History and the Far-Right in Current Spain
International Public HistoryThis article analyses the risks faced by practices associated with public history owing to the resurgence of the far-right in Spain. It critically examines the historical narratives embedded in specific historical shows and reenactments, which, instead ...
Alares López Gustavo
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source