Results 121 to 130 of about 220,864 (310)
НеофилологияINTRODUCTION. The purpose of the research is to study the urban text in the reflection of the artistic worldview of the historical novel by Odil Yoqubov “Treasures of Ulugbek”, which allows to consider the work based on the analysis of the place and ...
N. A. Ismatova
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
“They buried him at Worcester”: Heritage sites, historical fiction and Hilary Mantel’s Wolf Hall
While Hilary Mantel’s Booker-Prize-winning novel Wolf Hall has been subject to a range of critical approaches since its publication, no study yet exists which interrogates the novel’s interactions with the historical architecture and heritage sites it ...
Arnold, Lucy
core
Historia y Sociedad, 2011 The aim of this essay is to compare the political perspectives put forward by two historical novels tackling the theme of Colombia’s Independence: El General en su laberinto (GL) by Gabriel García Márquez, and Conviene a los felices permanecer en casa ...
Gustavo Forero Quintero
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
In today’s digital world, we are committed to digitizing thousands of handwritten transcriptions to preserve their content. Historical Arabic Handwritten Text Recognition (HAHTR) remains a challenge for computer vision systems, due to the many ...
Ahror, B., Meziane, F., Bouchal, H.
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source