Results 101 to 110 of about 1,186,802 (304)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Forecasting Enrollment Model Based on First-Order Fuzzy Time Series

open access: yes, 2005
This paper proposes a novel improvement of forecasting approach based on using time-invariant fuzzy time series. In contrast to traditional forecasting methods, fuzzy time series can be also applied to problems, in which historical data are linguistic ...
Konstantin Y., Degtiarev, Sah, Melike
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Türk Denizcilik Tarihi Öğretiminde Kullanılabilecek Romanlar Üzerine Bir Değerlendirme

open access: yesSakarya Üniversitesi Eğitim Fakültesi Dergisi, 2014
Bu çalışmanın amacı Türk denizcilik tarihi öğretiminde kullanılabilecek romanların değerlendirmesini yapmaktır. Bu amaçla literatür taraması yapılmış ilgili romanlar tespit edilmiştir. Çalışmanın yöntemi doküman analizine dayanmaktadır.
Özgür Aktaş
doaj  

Da Sterne alla critica dei romanzi inglesi nell’Epistolario di Foscolo

open access: yesCahiers d’Études Italiennes, 2015
The first part of this essay focuses on the comparison between Foscolo and Sterne, and more specifically on the echoes of Sterne’s prose in Foscolo’s Epistolario and their absence from subsequent writings, those that preceded and followed Foscolo’s self ...
Sandra Parmegiani
doaj   +1 more source

Pedestrian Trajectory Prediction with Structured Memory Hierarchies

open access: yes, 2018
This paper presents a novel framework for human trajectory prediction based on multimodal data (video and radar). Motivated by recent neuroscience discoveries, we propose incorporating a structured memory component in the human trajectory prediction ...
A Roy   +10 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Great Patriotic War as a Source of Plots for Modern Historical Fantastic Fiction

open access: yesФилологический класс, 2013
The author focuses on the modern Russian historical fantastic novel as part of modern historical discourse. The characteristics of the typical plot of the genre and the type of the main character are investigated and found interdependent.
doaj  

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