Results 81 to 90 of about 10,071,074 (300)

The historical novel

open access: yes, 1962
The Classical Form of the Historical Novel - Historical Novel and Historical Drama - The Historical Novel and the Crisis of Bourgeois - The Historical Novel of Democratic ...
Hannah Mitchell   +2 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Annual Report Kansas Historical Society, Inc. Fiscal Year 2013 Annual Report

open access: yes, 2007
In 2006 two annual reports were issued: one covering the activities of the Historical Society as a state agency , and one covering the activities of the Kansas State Historical Society Inc.
Kansas State Historical Society
core   +1 more source

The role of poetry in Nguyen Xuan Khanh’s novel “Ho Quy Ly”

open access: yesRUDN Journal of Studies in Literature and Journalism
The purpose of the study is to determine the role of poetic insertions in the novel “Ho Quy Ly” (2000) by the modern Vietnamese writer Nguyen Xuan Khanh (1933-1921) little studied in Russian and English-language literary criticism.
Ekaterina O. Muralova   +1 more
doaj   +1 more source

Christian truth and political power in Evelyn Waugh’s Helena [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Серия Филология, Журналистика
The novel Helena (1950) is analyzed as Evelyn Waugh’s profound statement on his most significant problems: the possibility to resolve the crises of the 20th-century consciousness through Christianity and on the nature of power.
Kabanova, Irina Valeryevna
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Sherlock Holmes with a lute and an imperial seal

open access: yesNeograeca Bohemica, 2020
The aim of this paper is to present a popular trilogy written by the contemporary Greek novelist and highly respected Byzantinist Panagiotis Agapitos (born 1959).
Vladimíra Zítková
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy