Results 51 to 60 of about 220,864 (310)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Educational potential of the historical novel genre [PDF]

, 2020
Главными признаками исторического романа как эпического жанра являются документальная основа, подлинные исторические события и люди. Исторический роман объединяет настоящую историю и фантазию, содержит жизнеописание выдающихся личностей, национальных ...
Bagicheva, N. V., Baltimova, M. R., Багичева, Н. В., Балтымова, М. Р.   +3 more
core   +1 more source

Questionner l’identité par le roman historique

Recherches
William Ospina’s Amazon trilogy (Ursúa, El país de la canela and La serpiente sin ojos) recounts Pedro de Ursúa’s Conquest and two expeditions to the Amazon rainforest.
Benjamin Delmotte
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Re-presenting the past : authenticity and the historical novel

, 2014
This project involved writing Turrwan (great man), a novel set in Queensland in the nineteenth century, and an investigation into the way historical novels portray the past.
Carroll, Richard J.
core  

Contemporary Seicento:On the Dark Background of the Italian Historical Novel [PDF]

, 2015
While the historical novel is a product of European Romanticism, the first Italian historical novel expresses the critical awareness of its origin against the dark background of the Seicento.
Davide Messina, Messina, Davide; id_orcid, Messina, Davide   +2 more
core   +1 more source

The New Historical Novel is a Historical Novel

International Journal of Education, Culture and Society
In these lines we expose that nowadays the beginning of a research work no longer has such clear and distinct categories as it was supposed just a few decades ago. The supposed solidity of some concepts is blurring as well as some disciplinary visions that were sure of their rigorous procedure, in fact, only widened the gap between the abstract world ...
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hugh Wynne, a Historical Novel

, 2010
"The writer suggested to a class of advanced students in historical criticism at Stanford that a few weeks be spent upon the critical examination of some historical novel.
Farrand, Max
core  

Landscapes of History in the Novels of Lawrence Norfolk

Prague Journal of English Studies, 2015
This article deals with novels by Lawrence Norfolk which are read with a focus on their visual quality and the way they depict history. It is argued that Norfolk’s historical novels are unique in their portrayal of “landscapes of history”, large canvases
Nagy Ladislav
doaj   +1 more source