Results 61 to 70 of about 174,958 (266)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Francesco Petrarca and the Parameters of Historical Research
Religions, 2012 Although scholars in the first two generations of humanism wrote the histories drawing heavily on ancient Roman sources, Petrarca was the first humanist historian to focuses on the history of ancient Roma.
Ronald Witt
doaj +1 more source
A Historical Perspective on Sepsis
The American Journal of Pathology, 2012 In North America, approximately 700,000 cases of sepsis occur each year, with mortality ranging between 30% and 50%. The American Journal of Pathology has featured numerous articles on the topic, revealing mechanistic insights gleaned from both experimental rodent models and human sepsis.
Ward, Peter A., Bosmann, Markus
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
EXPLORING THE HISTORICAL PERSPECTIVE OF MR. DAO DUY ANH THROUGH THE MEMOIR “EVENING REFLECTIONS”
Tạp chí Khoa họcThe memoir Evening Reflections - Nhớ nghĩ chiều hôm, with 30 chapters, encapsulates the turbulent life of Professor Dao Duy Anh, from his departure from Quang Binh and involvement in political activities to his dedicated career in teaching and ...
Ho Thi Lien Huong
doaj +1 more source
Mobility, Transport and Social Inclusion: Lessons from History
Social Inclusion, 2016 This paper argues that although it is now possible to travel more quickly and easily than ever before, transport-related social exclusion is more likely than it was in the past.
Colin Pooley
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Social Inclusion, 2015 This article argues that contemporary antislavery activism in the United States is programmatically undermined and ethically compromised unless it is firmly grounded in a deep understanding of the African American past. Far too frequently those who claim
James B. Stewart
doaj +1 more source