Results 71 to 80 of about 1,389,572 (306)
Are Delayed Issues Harder to Resolve? Revisiting Cost-to-Fix of Defects throughout the Lifecycle
, 2016 Many practitioners and academics believe in a delayed issue effect (DIE); i.e. the longer an issue lingers in the system, the more effort it requires to resolve.
Layman, Lucas +3 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Вестник Кемеровского государственного университета, 2015 The paper is devoted to the analysis of the process of creation and functioning of the Russian tourist portals linked with the use of technologies of augmented reality (qr-codes).
E. A. Kirsanova
doaj
A Multicriteria Approach for the Evaluation of the Sustainability of Re-use of Historic Buildings in Venice [PDF]
The paper presents a multiple criteria model for the evaluation of the sustainability of projects for the economic re-use of historical buildings in Venice.
Margaretha Breil +2 more
core
, 2008 This paper explores Dilthey’s radical transformation of epistemology and the human sciences through his projects of a critique of historically embodied reason and his hermeneutics of historically mediated life.
Nelson, Eric Sean
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Supporting climate change adaptation using historical climate analysis [PDF]
, 2019 Climate change and variability presents a major challenge for rural communities in developing countries. Bridging organisations have a role in helping align top-down and local perspectives, mediating the communication messages that ultimately shape the ...
Dorward, Peter +3 more
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Ciência da Informação, 2008 Narrativas de histórias é uma técnica de gestão do conhecimento para compartilhamento de experiências, pensamentos e valores no ambiente organizacional.
Valério Brusamolin, Eduardo Moresi
doaj +1 more source