Results 61 to 70 of about 74,612 (265)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The city branding potential of Sakarya: A tourism-oriented evaluation
Journal of Design for Resilience in Architecture and PlanningWith the rise of global competition, developing city branding strategies has become vital for urban centres. The unique features and values of cities, especially their geographical, cultural, and historical traits, play a crucial role in shaping city ...
Esra Parıldı, Güliz Öztürk
doaj +1 more source
History as an Instrument in the Development of Historical Danish Villages
Buildings, 2016 A central contemporary societal discussion in Denmark concerns settlements that have poor connectivity and are geographically distant to main towns and cities. These settlements are called “outskirts.” Historically significant villages in these outskirts
Morten Birk Jørgensen
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Historical Workstation Project : Part 1
, 1991 Historical Social Research, 16(4), 51 ...
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Historical-futurological projects: Utopian models of V.F. Odoevsky and A.V. Chayanov
RUDN journal of SociologyVladimir Fedorovich Odoevsky (1804-1869) and Alexander Vasilyevich Chayanov (1888-1937) are remarkable thinkers of the romantic school, like Ernst Theodor Hoffmann (with whom they are often compared), and wrote mystical-fantastical works in the spirit of
A. M. Nikulin, I. V. Trotsuk
doaj +1 more source