Results 71 to 80 of about 1,401,279 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Enhancing data reuse in tunnelling site investigation through transfer learning-based historical data mining

Underground Space
Vast amounts of valuable historical tunnelling site investigation data remain underutilized due to inefficient content-based archiving and searching tools. This study introduces a novel data-driven framework that integrates transfer learning with reverse
Jiawei Xie, Baolin Chen, Shui-Hua Jiang, Hongyu Guo, Si Xie, Jinsong Huang   +5 more
doaj   +1 more source

Delirium and historical project

, 2008
Thesis: wissenschaftliche Zeitschrift der Bauhaus-Universität Weimar, vol. 49, 2003, no.
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Problems of assessing the duration and cost of restoration projects on the example of Poland, Slovakia and Lithuania

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2018
The restoration of existing structures, especially historical ones, is a complicated endeavour. The often insuffi cient identification of the extant state of a building, the possibility of archaeological fi ndings and the necessary procedures involving ...
Elżbieta Radziszewska-Zielina, Bartłomiej Szewczyk, Bartłomiej Sroka, Grzegorz Śladowski, Peter Mesároš, Vladislavas Kutut   +5 more
doaj   +1 more source

Teachers’ Challenges of Using Local History Projects to Develop Learners’ Historical Skills – A Case Study of Motheo Education District [PDF]

Journal of Education and Learning Technology
This study explored the teachers’ challenges in using local history projects to develop learners’ historical skills. Despite the importance of local history projects in developing learners’ historical skills and knowledge, there is evidence that teachers
Zwelinjane Mbatha, Boitumelo Moreeng
doaj   +1 more source

A Multicriteria Approach for the Evaluation of the Sustainability of Re-use of Historic Buildings in Venice [PDF]

The paper presents a multiple criteria model for the evaluation of the sustainability of projects for the economic re-use of historical buildings in Venice.
Margaretha Breil, Paolo Rosato, Silvio Giove   +2 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Narrativas de histórias: um estudo preliminar na gestão de projetos de Tecnologia da Informação

Ciência da Informação, 2008
Narrativas de histórias é uma técnica de gestão do conhecimento para compartilhamento de experiências, pensamentos e valores no ambiente organizacional.
Valério Brusamolin, Eduardo Amadeu Dutra Moresi   +1 more
doaj  

A Hedged Monte Carlo Approach to Real Option Pricing

, 2015
In this work we are concerned with valuing optionalities associated to invest or to delay investment in a project when the available information provided to the manager comes from simulated data of cash flows under historical (or subjective) measure in a
A. Borison, A. Dixit, A. Dixit, A.G.N. Novaes, C.C. Chen, E. Gobet, F. Hubalek, F.A. Longstaff, G. Mittal, G.H. Golub, H. Pham, J. Oldenburg, J.A. Primbs, J.E. Ingersoll, J.F. Shapiro, J.L. Paddock, J.P. Lemor, L. Moro, L. Trigeorgis, L. Trigeorgis, L.G. Papageorgiou, L.V. Gastel, M. Musiela, M. Potters, M. Schweizer, M. Schweizer, M.J. Brennan, M.R. Grasselli, M.R. Grasselli, N. Karoui El, N. Sahinidis, O. Bobrovnytska, P. Glasserman, R. McDonald, S. Mathews, S. Titman, S.C. Myers, T. Copeland, T. Copeland, V. Henderson   +39 more
core   +1 more source