Results 121 to 130 of about 834,295 (297)

Elements of a First-Person Ecology: Historical Roots, Recognition and Ecospirituality

open access: yesPhilosophies
Starting from the observation that there is a gap between knowledge of the environmental sciences and practical engagement, for example, in climate change or biodiversity loss, this article explores one possible explanation for this situation—namely, the
Esteban Arcos   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Colonialism, elite Formation and corruption [PDF]

open access: yes
This paper argues that corruption in developing countries has deep historical roots; going all the way back to the characteristics of their colonial experience.
Kyriakos C. Neanidis, Luis Angeles
core  

A Brief Overview of the Life and Work of Lyon Henry Appleby, M.D. (1895-1970). [PDF]

open access: yes, 2016
The life and work of Dr. Lyon Henry Appleby, M.D., portrays the essence of a devoted clinician committed to scholarly excellence. Born in Deseronto, Ontario, in 1895 and passing in 1970, Dr.
Cowan, Scott W.   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Understanding career calling: historical roots and practical relevance for school counselors

open access: yesJurnal Konseling dan Pendidikan
This article critically examines the origins and evolution of the term "career calling" and its relevance for school counselors. Tracing its roots from Ancient Greece to modern times, the concept of career calling has shifted from a spiritual vocation to
Robbani Alfan   +3 more
doaj   +1 more source

Linking Historical Roots and Current Methodologies of Engineering Systems [PDF]

open access: yes, 2008
This paper reviews the historical context and present impact of two sets of literature: the work of Joseph Schumpeter and the field of Strategy Development.
Santen, Nidhi R., Wood, Danielle
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Historical Roots of the Problems in Relations between Russia andGermany

open access: yesVestnik RUDN. International Relations, 2011
Russia has had close contacts with no one of the West European nations but Germans. Experience of this interaction is unique. Russia has always provoked contradictory feelings in Germans: from almost mystical adoration to full antagonism.
А А Gabiev
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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