Results 131 to 140 of about 834,295 (297)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Faber/Vates. Historische en mythologische modellen voor de kunstenaarsrol in de oudheid [PDF]
, 2009 What do we mean when we call someone an ‘artist’? There’s something about the word that eludes definition. For besides the skills of a craftsman (faber, in Latin), the artist is supposed to possess a certain indefinable, privileged insight or inspiration
Sels, Nadia
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Exporting the American Model:Historical Roots of Globalization [PDF]
The late 1990s was a period of Panglossian optimism. The world, we were told, was getting smaller, increasingly seamless and it all had to do with ‘globalization’ (Ohmae 1994, Held et al. 1999, Giddens 1999, Friedman1999).
Djelic, Marie-Laure
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Historical roots of pain management in infants: A bibliometric analysis using reference publication year spectroscopy. [PDF]
Paediatr Neonatal Pain, 2020 Anand KJS +4 more
europepmc +1 more source
Financial collateral Arrangements under Directive 2002/47/ec of the European Parliament and of the Council of 6 June 2002 [PDF]
The aim in this article is to compare effect of financial collateral arrangements under Directive 2002/47 EC. The starting point is the definitions of these contracts provided by the Financial Collateral Directive.
Ivan, Mangatchev
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source