Results 91 to 100 of about 1,885,281 (312)

Asian Flu Pandemic in Indonesia, 1957: Government and Public Response

open access: yesIHiS (Indonesian Historical Studies)
This study aims to analyze the 1957 Asian Flu Pandemic in Indonesia, focusing on the government and public response. The 1957 Asian Flu Pandemic was the second pandemic in the world after the 1918 Spanish Flu Pandemic. The pandemic was caused by the H2N2
Muhammad Fakhriansyah   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

FROM HISTORICAL CHANGE TO HISTORICAL KNOWLEDGE: DIRECTIONS OF A NEW EPISTEMOLOGY OF THE HUMAN SCIENCES [PDF]

open access: yesLogos & Episteme: An International Journal of Epistemology, 2013
The present paper endeavors to trace the sketch of a possible epistemology of the human sciences. In this sense it begins with the determination of the object of knowledge in the human sciences through a careful examination of the reality of history and ...
Adrian COSTACHE
doaj  

Du déterminisme biologique au déterminisme social

open access: yesSocio, 2016
Historical semantics, while being opposed to the idea of linear progress, does enable us to show that notions of biological determinism and social determinism were broadly conceived as being complementary.
Marc Joly
doaj   +1 more source

Gender Is a Natural Kind with a Historical Essence [PDF]

open access: yes, 2012
Traditional debate on the metaphysics of gender has been a contrast of essentialist and social-constructionist positions. The standard reaction to this opposition is that neither position alone has the theoretical resources required to satisfy an ...
Bach, Theodore
core  

Neither Logical Empiricism nor Vitalism, but Organicism: What the Philosophy of Biology Was [PDF]

open access: yes, 2015
Philosophy of biology is often said to have emerged in the last third of the twentieth century. Prior to this time, it has been alleged that the only authors who engaged philosophically with the life sciences were either logical empiricists who sought to
Gawne, Richard, Nicholson, Daniel J.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Nota a "La teoria dell’Evoluzione nella cultura moderna", di Giorgio Forti (25/10/13) [con traduzione inglese]

open access: yesNóema, 2013
It has never existed for us a world without any relationship to our cognitive sciences  and to our words. Natural sciences, like all sciences in general, are made of a series of historical operations.
Carlo Sini
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Historical sciences in search of object

open access: yesMemoria y Civilización, 2012
Science’ main problem is to find his subject. This subject conditioned the principles and the method to be used. In the case of the Historical Science, the subject must be constructed from fragmentary data because History deals with that no longer exists.
Armando Segura Naya
doaj  

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