Results 91 to 100 of about 1,883,239 (312)
Gender Is a Natural Kind with a Historical Essence [PDF]
, 2012 Traditional debate on the metaphysics of gender has been a contrast of essentialist and social-constructionist positions. The standard reaction to this opposition is that neither position alone has the theoretical resources required to satisfy an ...
Bach, Theodore
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FROM HISTORICAL CHANGE TO HISTORICAL KNOWLEDGE: DIRECTIONS OF A NEW EPISTEMOLOGY OF THE HUMAN SCIENCES [PDF]
Logos & Episteme: An International Journal of Epistemology, 2013 The present paper endeavors to trace the sketch of a possible epistemology of the human sciences. In this sense it begins with the determination of the object of knowledge in the human sciences through a careful examination of the reality of history and ...
Adrian COSTACHE
doaj
Du déterminisme biologique au déterminisme social
Socio, 2016 Historical semantics, while being opposed to the idea of linear progress, does enable us to show that notions of biological determinism and social determinism were broadly conceived as being complementary.
Marc Joly
doaj +1 more source
Neither Logical Empiricism nor Vitalism, but Organicism: What the Philosophy of Biology Was [PDF]
, 2015 Philosophy of biology is often said to have emerged in the last third of the twentieth century. Prior to this time, it has been alleged that the only authors who engaged philosophically with the life sciences were either logical empiricists who sought to
Gawne, Richard, Nicholson, Daniel J.
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Nóema, 2013 It has never existed for us a world without any relationship to our cognitive sciences and to our words. Natural sciences, like all sciences in general, are made of a series of historical operations.
Carlo Sini
doaj +1 more source
Historical sociology of the city [PDF]
, 2003 About the book: This Handbook consists of 26 chapters on historical sociology. It is divided into three parts. Part One is devoted to Foundations and covers Marx, Weber, evolutionary and functionalist approaches, the Annales School, Elias, Nelson and ...
Isin, Engin F.
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Historical sciences in search of object
Memoria y Civilización, 2012 Science’ main problem is to find his subject. This subject conditioned the principles and the method to be used. In the case of the Historical Science, the subject must be constructed from fragmentary data because History deals with that no longer exists.
Armando Segura Naya
doaj