Results 111 to 120 of about 353,625 (313)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Historical Calibration of a Water Account System [PDF]
Models that are used for future based scenarios should be calibrated with historical water supply and use data. Historical water records in Australia are discontinuous, incomplete and often incongruently disaggregated.
Timothy M Baynes +2 more
core
17th International Congress of Historical Sciences : organization and program [PDF]
, 2008 17e Congres International des Sciences Historiques : organisation et programme17th International Congress of Historical Sciences : organization and ...
core +3 more sources
Preotul Gheorghe I. Cotenescu (1886-1965), protopsalt, profesor, compozitor, dirijor, publicist şi om politic [PDF]
Studii si Cercetari de Istoria Artei : Teatru, Muzică, Cinematografie, 2015 The intellectual portrait of Father Gheorghe I. Cotenescu sketched out in this essay performs a dual function. While paying tribute to the work and fate of a neglected, but fascinating inter-war scholar, it serves as a tool which allows us to focus on ...
Radu Petrescu
doaj
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Anastasiіa Grinchenko: Sketches of Social and Political Activity in Kyiv during 1905–1907
Київські історичні студіїThis paper, based on archival sources, highlights the period of Anastasia Grinchenko’s life during her social and political activities in Kyiv (1905 — April 1907).
Ninel Klymenko
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
AntropoWebzin, 2010 This article is based on the anthropological fiel-dwork research in the Litvínov–Janov neighborhood (located in northwest of the Czech Republic), which was conducted bythe students of the Department of Anthropological and Historical Sciences (University ...
Michal Tošner +5 more
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source