Results 91 to 100 of about 15,478,074 (304)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FROM HISTORICAL CHANGE TO HISTORICAL KNOWLEDGE: DIRECTIONS OF A NEW EPISTEMOLOGY OF THE HUMAN SCIENCES [PDF]
Logos & Episteme: An International Journal of Epistemology, 2013 The present paper endeavors to trace the sketch of a possible epistemology of the human sciences. In this sense it begins with the determination of the object of knowledge in the human sciences through a careful examination of the reality of history and ...
Adrian COSTACHE
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Historical sciences in search of object
Memoria y Civilización, 2012 Science’ main problem is to find his subject. This subject conditioned the principles and the method to be used. In the case of the Historical Science, the subject must be constructed from fragmentary data because History deals with that no longer exists.
Armando Segura Naya
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Health preservation during travel: Evidence from the medieval medical manuscript Cantica canticorum Avicenne cum commento Averrois [PDF]
Acta Historiae Medicinae, Stomatologiae, Pharmaciae, Medicinae VeterinariaeThis paper examines medieval recommendations for maintaining health during travel, as recorded in the manuscript Cantica canticorum A vicenne cum commento A verrois, preserved in the Metropolitan Library of Zagreb. It is a Latin translation of Avicenna's
Grbavac Branka, Dugac Željko
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Preotul Gheorghe I. Cotenescu (1886-1965), protopsalt, profesor, compozitor, dirijor, publicist şi om politic [PDF]
Studii si Cercetari de Istoria Artei : Teatru, Muzică, Cinematografie, 2015 The intellectual portrait of Father Gheorghe I. Cotenescu sketched out in this essay performs a dual function. While paying tribute to the work and fate of a neglected, but fascinating inter-war scholar, it serves as a tool which allows us to focus on ...
Radu Petrescu
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