Results 81 to 90 of about 2,467,270 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

THE INTEGRATION OF THE EDUCATIONAL SPACE IN SECONDARY SCHOOLS AND UNIVERSITIES AS A PRE-REQUISITE FOR THE FORMATION OF HISTORICAL THINKING

open access: yesИнтеграция образования, 2017
Introduction: features and ways of historical thinking development of a student as a subject of educational and professional activity are analyzed. The aim of the research is to monitor the degree of formation of the features of historical thinking in ...
Lyudmila V. Shukshina   +2 more
doaj   +1 more source

Registration cards of Kazan doctors as a source on the history of the Russian intelligentsia during the Civil War

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2020
Registration cards of doctors, a little-studied source on the history of the Russian intelligentsia during the Civil War, were studied. The analysis is based on more than 200 cards collected by the Health Department of the Kazan Province Executive ...
A.A. Salnikova, R.R. Khaziakhmetova
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Cartoons and economics: general analysis based on colombian economic cartoons. [PDF]

open access: yes
May cartoons be considered as a viable and credible source for the study of economics? There is hardly any research on the subject, even though there is a quite significant amount of cartoons with economic content.
Rodríguez Lesmes, Paul Andrés   +1 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Monograph Review by: Dolgikh A.N. (2024). “But a Terrible Thought Darkens the Soul Here...”: The Problem of Serfdom in the Works of Russian Writers of the 18th – first half of the 19th Centuries. Historiographical Essays. Lipetsk, Lipetsk State Pedagogical P. Semenov-Tyan-Shansky University Publ., 365 p.

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The scientific significance of the publication is related to the need to constantly emphasize the studying fiction importance as a valuable historical source.Materials and Methods. The historiographical source is a monograph by A.N.
V. V. Kanishchev
doaj   +1 more source

Preserving newspapers: National and international cooperative efforts [PDF]

open access: yes, 1991
Historians have always turned to newspapers to see how events were interpreted at the time that they occurred. Now, more than ever, with an increased interest in social history and in the daily life of the common person, historians have come to ...
Swartzburg, Susan Garrison
core  

E 0336-248 : A New BL Lac Object Found by an Old Einstein [PDF]

open access: yes, 1997
We obtained new ROSAT HRI and optical observations in the field of the Einstein X-ray source E 0336-248, which we use to identify it as a 19th magnitude BL Lacertae object at z=0.251 with an X-ray luminosity of 10^45 erg/s.
Eracleous, M.   +2 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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