Results 191 to 200 of about 10,380,327 (309)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Latin America: History and Criticism

Iberoamericana. América Latina - España - Portugal, 2016
Albert Manke, Stefan Rinke, Josef Opatrný, Raquel Gil Montero, Luz Ailin Lozada, Raquel Arias Careaga, Peter Fleer, Ludger Pries, Katrina Böse, Veit Straßner   +9 more
doaj   +1 more source

Caribbean Islands facilitated the colonization of Western Hemisphere barn owls, yet experienced rampant extinction. [PDF]

Proc Biol Sci
Zhao M, Steadman DW, LeFebvre MJ, Guralnick RP, Doby JR, Allen JM, Oswald JA.   +6 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Your History Department & America 250

Your History Department and America 250, a presentation made at the Ohio Valley History Conference, hosted by Austin Peay State University. Dr. Christy Spurlock, Education Curator at the KY Museum, has hosted several America 250 programs and offers ...
Spurlock, Christy L
core  

Omer Bartov, Genocide, the Holocaust and Israel-Palestine. First-Person History in Times of Crisis. New York, Bloomsbury Academic 2023

Historische Zeitschrift
Penslar Derek J.
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

SIMoNA: Sky Island Mammals of North America. [PDF]

J Mammal
Cook K, Adhikari B, Frey JK, Arbogast BS, Rowsey D, Upham N, Burger JR.   +6 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals. [PDF]

PLoS Biol
Lin M, Chakraborty S, Amorim CEG, Nigenda-Morales SF, Beichman AC, Nuñez-Valencia PG, Mah JC, Robinson JA, Kyriazis CC, Huber CD, Webb AE, Kocher SD, Archer FI, Moreno-Estrada A, Wayne RK, Lohmueller KE.   +15 more
europepmc   +1 more source