Results 91 to 100 of about 9,797,833 (343)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Using Historical Sites in East Kalimantan for Education: Challenges and Opportunities

open access: yesYupa: Historical Studies Journal, 2018
The historical site can be used as a source of learning history, a model of learning history, media history learning, to enhance literacy history or as historical attractions.
Muhammad Azmi
doaj   +1 more source

Fostering cognitive strategies for learning with 360° videos in history education contexts. [PDF]

open access: yesUnterrichtswissenschaft, 2022
Nachtigall V   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Taking the perspective of the other seriously? understanding historical argument Levando a sério a perspectiva do outro: compreendendo o argumento histórico

open access: yesEducar em Revista, 2011
This paper discusses the nature of argument and its role and importance in historical learning. The paper describes pedagogic strategies developed to help school pupils understand what argument is, model how arguments work and think about how arguments ...
Arthur Chapman
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

From the history of the development of physical culture and sports education in Kabardino-Balkaria

open access: bronze, 2023
A. M. Tkhazeplov   +3 more
openalex   +1 more source

History Education and Conflict Transformation: Social Psychological Theories, History Teaching and Reconciliation

open access: yes, 2017
This volume discusses the effects, models and implications of history teaching in relation to conflict transformation and reconciliation from a social-psychological perspective.
Charis Psaltis   +2 more
semanticscholar   +1 more source

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