Results 71 to 80 of about 958,452 (268)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Fostering cognitive strategies for learning with 360° videos in history education contexts. [PDF]

open access: yesUnterrichtswissenschaft, 2022
Nachtigall V   +4 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

LİSE ÖĞRENCİLERİNİN GÖZÜYLE TARİH ÖĞRETMENİ: BİR METAFOR ANALİZİ

open access: yesTurkish History Education Journal, 2019
Metafor genellikle; benzetme, kinaye ve teşbih maksadıyla kullanıla gelmiştir ayrıca bir kavrama yönelik, bireylerin zihinsel şemalarının belirlenmesine de olanak sağlar. Bu doğrultuda lise öğrencilerinin Tarih Öğretmeni’ne ilişkin algılarının metaforlar
Yasemin ER TUNA
doaj   +1 more source

History, Education and Genre

open access: yesRevista Voces de la Educación, 2017
Although the access for women into the Peruvian educative system is high, it persists the inequality in the levels of schooling and formation; the imbalance between the urban and rural access, and a high percentage of female illiteracy as a result of the historic, social and cultural conditions studied in this work from a perspective of genre and ...
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

TARİH ÖĞRETİMİNE YENİ BİR YAKLAŞIM: BÜYÜK TARİH PROJESİ

open access: yesTurkish History Education Journal, 2019
Big History Project (BHP) Büyük Patlama'dan günümüze kadar olan tarihi, disiplinlerarası bir biçimde kapsayan pilot okullar, öğretmenler ve eğitimciler için oluşturulmuş ücretsiz ve çevrimiçi bir eğitim platformudur.
Sibel YALI
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

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