Results 71 to 80 of about 1,013,070 (269)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Narrative inquiry and historical skills. A study in teacher training

Revista Electrónica de Investigación Educativa, 2017
This paper addresses narrative thinking and literacy levels in future primary school teachers in Spain. It uses the study of a historical synthesis of one of the main narratives in Spanish history: the Christian expansion through Muslim territories in ...
Cosme J. Gómez Carrasco, Jorge Sáiz
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Aesthetic and Formative values of Mural Painting Scenes in Ancient Egyptian Art As a Suggested Introduction to Appreciating Contemporary Wooden Murals

Journal of Architecture, Art & Humanistic Science
The research deals with studying the aesthetic and plastic values of mural scenes in ancient Egyptian art and using them as a suggested entry point for appreciating contemporary wooden murals, by clarifying the importance of wall painting in general and ...
Dr. Dalia Mohamed Mahmoud Sharaf Lecturer of Art History and Appreciation, Department of Art Education, Faculty of Specific Education, Alexandria University, Dr. Dalal Al-Haylam Fahd Ghazi Al-Mutairi Secondary Primary Teacher at the College of Education, Public Authority for Applied Sciences - State of Kuwait, Dr. Hajar Mohamed Abdel Raouf Metwally Assistant Lecturer, Department of Art Education, Faculty of Specific Education, Alexandria University   +2 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Effectiveness of Case-Based and Project-Based Learning in Promoting Sustainability Awareness: A Comparative Study

Journal of Education Technology
History learning, which is still dominated by conventional methods, tends to focus only on the cognitive aspect and has not fully addressed the affective and conative dimensions that are crucial in fostering students’ ecological awareness.
Khusnul Khotimah, Mochamad Kamil Budiarto, Arsyananda Rabbani, Leni Marpelina, Leo Andrew B. Biclar   +4 more
doaj   +1 more source

A Hypermedia-Supported program and its effect on developing historical reasoning skills among first year secondary school students [PDF]

International Journal of Instructional Technology and Educational Studies
This study investigated the effect of a hypermedia-supported program on developing historical reasoning skills among first-year secondary school students in Egypt.
kholoud ibrahem, Samia Fayed
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source