Results 91 to 100 of about 16,191,908 (309)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Using Historical Sites in East Kalimantan for Education: Challenges and Opportunities

open access: yesYupa: Historical Studies Journal, 2018
The historical site can be used as a source of learning history, a model of learning history, media history learning, to enhance literacy history or as historical attractions.
Muhammad Azmi
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Taking the perspective of the other seriously? understanding historical argument Levando a sério a perspectiva do outro: compreendendo o argumento histórico

open access: yesEducar em Revista, 2011
This paper discusses the nature of argument and its role and importance in historical learning. The paper describes pedagogic strategies developed to help school pupils understand what argument is, model how arguments work and think about how arguments ...
Arthur Chapman
doaj   +1 more source

The effect of online learning in modern history education. [PDF]

open access: yesHeliyon, 2022
Malysheva O   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Accounting History Education Committee [PDF]

open access: yes, 1985
The Accounting History Education Committee has been active in three areas during the past year. The most significant activity was the agreement with Random House for the publication of a short book of biographies of noted ...
Accounting History Education Committee, Academy of Accounting Historians.
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