Results 101 to 110 of about 9,797,833 (343)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Teacher Attitudes Toward Game-based Learning in History Education
, 2017 Game-based learning (GBL) is an emerging field reaching new contexts. Research has reported about students’ rich use of digital games and the learning potential of GBL in traditional school subjects. Digital games have been tested as educational tools in
Peter Mozelius +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
LİSE ÖĞRENCİLERİNİN GÖZÜYLE TARİH ÖĞRETMENİ: BİR METAFOR ANALİZİ
Turkish History Education Journal, 2019 Metafor genellikle; benzetme, kinaye ve teşbih maksadıyla kullanıla gelmiştir ayrıca bir kavrama yönelik, bireylerin zihinsel şemalarının belirlenmesine de olanak sağlar. Bu doğrultuda lise öğrencilerinin Tarih Öğretmeni’ne ilişkin algılarının metaforlar
Yasemin ER TUNA
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Nordic Journal of Digital Literacy, 2013 Digital technologies have the potential to enable history teachers to engage student learning, meet diverse learning styles, present a diversity of perspectives, and foster historical inquiry.
Julie A. Corrigan +3 more
doaj
TARİH ÖĞRETİMİNE YENİ BİR YAKLAŞIM: BÜYÜK TARİH PROJESİ
Turkish History Education Journal, 2019 Big History Project (BHP) Büyük Patlama'dan günümüze kadar olan tarihi, disiplinlerarası bir biçimde kapsayan pilot okullar, öğretmenler ve eğitimciler için oluşturulmuş ücretsiz ve çevrimiçi bir eğitim platformudur.
Sibel YALI
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source