Results 61 to 70 of about 2,077,438 (389)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Economic and Historical Foundation of the Common Agricultural Policy in Europe [PDF]

The Common Agricultural Policy (CAP) was founded in the 1950s with price support as the main policy instrument. Despite massive criticism from both within and outside the EU, price support remains the backbone of the CAP.
Zobbe, Henrik
core   +4 more sources

Realising the potential of the family history in risk assessment and primary prevention of coronary heart disease in primary care: ADDFAM study protocol

BMC Health Services Research, 2009
Background Coronary heart disease (CHD) is the leading cause of death in the developed world, and its prevention a core activity in current UK general practice.
Kai Joe, Evans Phil H, Middlemass Jo, Sach Tracey, Saukko Paula, Armstrong Sarah, Qureshi Nadeem, Farrimond Hannah, Humphries Steve E   +8 more
doaj   +1 more source

The sword of god: Plague and episcopal authority in the Late Antique West [PDF]

This thesis examines three major historical figures of Early Medieval Europe to discover the attitudes and responses to the plague: Pope Gregory the Great, Gregory of Tours, and the Venerable Bede.
Kenney, Amanda
core   +1 more source

Comparative historical sociology and the State : problems of method [PDF]

, 2016
Historical sociology can be understood both as a specific sub-field of sociology and as providing general conceptual underpinnings of the discipline, to the extent that it provides an understanding of the specificity of the modern state and the perceived
Anderson D, Arjomand SA, Bhambra GK, Bruun HH, Dunbar-Ortiz R, Eisenstadt SN, Elkins C, Gurminder K. Bhambra, Holmwood J, Kalberg S, Knöbl W, Mommsen WJ, Mommsen WJ, Moore B, Poggi G, Tilly C, Wagner P, Wallerstein I, Weber M, Wolin SS   +19 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Buffon, Jefferson and the theory of New World degeneracy

Evolution: Education and Outreach, 2019
In his magnum opus, Natural History: General and Particular, Count Buffon, one of the leading natural historians of the 18th century, argued that all life in the New World, particularly North America, was degenerate—weaker, smaller and feebler—than life ...
Lee Alan Dugatkin
doaj   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

New Directions in the History of Written Culture

Culture & History Digital Journal, 2012
This article reviews some new directions in the history of writing practices, concentrating on Western Europe and the Americas in the nineteenth and early twentieth centuries.
Martyn Lyons
doaj   +1 more source