Results 41 to 50 of about 472,423 (265)

Buffon, Jefferson and the theory of New World degeneracy

open access: yesEvolution: Education and Outreach, 2019
In his magnum opus, Natural History: General and Particular, Count Buffon, one of the leading natural historians of the 18th century, argued that all life in the New World, particularly North America, was degenerate—weaker, smaller and feebler—than life ...
Lee Alan Dugatkin
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Ukraine before Statehood: A Blind Spot in Western European Historiography of/on Europe since 1991?

open access: yesZeitschrift für Ostmitteleuropa-Forschung
This article focuses on the relationship between Ukraine and Europe in historiography. It asks whether Ukraine was a blind spot in Western European historiography on Europe since 1991.
Joachim Berger
doaj   +1 more source

Hacia una historiografía de la enfermedad: Prácticas, profesiones y enfermos

open access: yesMemoria y Civilización, 2008
The article considers the development of the history of medicine since its institutionalization, in 19th century Europe. The historiographical tendencies that conditioned this development of the branch of learning are analysed.
Pilar León Sanz
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

La “potenza del negativo” come destino dell’Europa: un libro di Biagio de Giovanni [PDF]

open access: yesDemocrazia e Diritti Sociali
In this contribution we analyze the constitutive connection of Europe and philosophy in the thought of Biagio de Giovanni, within a properly ‘ontology’ field, according to a ‘fundamental speculative figure’ which is articulated in an ‘ontology of being ...
Antonio Luongo
doaj  

May 1968 Protests in France in the Collective Memory of the European Commission Politicians

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The May 1968 protests are an important place of remembrance in the history of Europe. Methods and materials. The author uses the methods of studying collective memory to analyze the image of the May protests in the collective memory ...
Nikita Bulavintsev
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

New Directions in the History of Written Culture

open access: yesCulture & History Digital Journal, 2012
This article reviews some new directions in the history of writing practices, concentrating on Western Europe and the Americas in the nineteenth and early twentieth centuries.
Martyn Lyons
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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