Results 61 to 70 of about 472,423 (265)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Literární komparatistika, areálová/kulturní studia, teorie literárních dějin a problém hodnoty v současné literárněvědné praxi

open access: yesOpera slavica, 2013
The author of the present study deals with the crucial and topical problems concerning both the comparative studies and area/cultural studies as we ll as the history and theory of national literatures and the comparative studies and their methodology in ...
Ivo Pospíšil
doaj  

Why Religion Matters: Montenegro’s Sacred Nationhood in a Time of Contestation

open access: yesColloquia Humanistica
This book review offers a critical assessment of Emil Hilton Saggau’s Nationalisation of the Sacred. Although Saggau’s work seems to propose a concise history of Montenegro through the lens of Orthodox historiography, the main argumentation provides ...
Francesco Trupia
doaj   +1 more source

Migration patterns of subgenus Alnus in Europe since the last glacial maximum: a systematic review.

open access: yesPLoS ONE, 2014
Background/aimsRecently, new palaeoecological records supported by molecular analyses and palaeodistributional modelling have provided more comprehensive insights into plant behaviour during the last Quaternary cycle. We reviewed the migration history of
Jan Douda   +7 more
doaj   +1 more source

A « Third generation » ? Doing Environmental History in Europe the Early 21st Century

open access: yes, 2022
Dans l’un des derniers bilans de l’historiographie états-unienne, Paul Sutter reprenait une chronologie américano-centrée pour évoquer la genèse d’une « troisième génération » de l’histoire environnementale. Dans cette réflexion, la première génération désigne celle des auteurs qui imposèrent la question environnementale dans les programmes de ...
openaire   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Exiles from the Netherlands: A Rhizomatic Approach to Dutch Hip Hop History

open access: yesTijdschrift voor Mediageschiedenis
Mainstream canonisation of Hip Hop history in the Netherlands has mainly focused on the country’s West, and often relegates anglophone rap to a footnote in favour of Dutch-language rap. I offer an alternative reading by approaching the Netherlands’ early
Dastan Abdali
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

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