Results 71 to 80 of about 434,558 (341)

Migration patterns of subgenus Alnus in Europe since the last glacial maximum: a systematic review.

PLoS ONE, 2014
Background/aimsRecently, new palaeoecological records supported by molecular analyses and palaeodistributional modelling have provided more comprehensive insights into plant behaviour during the last Quaternary cycle. We reviewed the migration history of
Jan Douda, Jana Doudová, Alena Drašnarová, Petr Kuneš, Věroslava Hadincová, Karol Krak, Petr Zákravský, Bohumil Mandák   +7 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Material Culture of Road Safety: Road Safety as Museum Display?

Journal of Road Safety, 2009
The museum does not usually spring to mind as a site for road safety promotion but no other institution has so much involvement in collecting and displaying the material culture of motoring and interpreting its history for the general public.
Jennifer Clark
doaj  

Why Religion Matters: Montenegro’s Sacred Nationhood in a Time of Contestation

Colloquia Humanistica
This book review offers a critical assessment of Emil Hilton Saggau’s Nationalisation of the Sacred. Although Saggau’s work seems to propose a concise history of Montenegro through the lens of Orthodox historiography, the main argumentation provides ...
Francesco Trupia
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Literární komparatistika, areálová/kulturní studia, teorie literárních dějin a problém hodnoty v současné literárněvědné praxi

Opera slavica, 2013
The author of the present study deals with the crucial and topical problems concerning both the comparative studies and area/cultural studies as we ll as the history and theory of national literatures and the comparative studies and their methodology in ...
Ivo Pospíšil
doaj  

Pollen‐based quantitative reconstructions of Holocene regional vegetation cover (plant‐functional types and land‐cover types) in Europe suitable for climate modelling

Global Change Biology, 2015
We present quantitative reconstructions of regional vegetation cover in north‐western Europe, western Europe north of the Alps, and eastern Europe for five time windows in the Holocene [around 6k, 3k, 0.5k, 0.2k, and 0.05k calendar years before present ...
Anna-Kari Trondman, M. Gaillard, F. Mazier, S. Sugita, R. Fyfe, A. Nielsen, C. Twiddle, P. Barratt, H. Birks, A. Bjune, L. Björkman, A. Broström, C. Caseldine, Rémi David, J. Dodson, W. Dörfler, E. Fischer, B. Geel, T. Giesecke, Tove Hultberg, L. Kalniņa, M. Kangur, P. Knaap, T. Koff, P. Kuneš, P. Lagerås, M. Latałowa, J. Lechterbeck, C. Leroyer, M. Leydet, M. Lindbladh, L. Marquer, F. Mitchell, B. Odgaard, S. Peglar, T. Persson, A. Poska, M. Rösch, H. Seppä, S. Veski, L. Wick   +40 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Exiles from the Netherlands: A Rhizomatic Approach to Dutch Hip Hop History

Tijdschrift voor Mediageschiedenis
Mainstream canonisation of Hip Hop history in the Netherlands has mainly focused on the country’s West, and often relegates anglophone rap to a footnote in favour of Dutch-language rap. I offer an alternative reading by approaching the Netherlands’ early
Dastan Abdali
doaj   +1 more source