Results 141 to 150 of about 8,633,749 (309)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Aggregate Matching Function. The Case of Poland [PDF]
The main goal of this paper is to analyze the matching function in the Polish labour market in 1994-2008. Matching function is the relationship between outflows from unemployment to employment and the number of unemployed persons and vacancies as well as
Sylwia Roszkowska
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Numerical modeling and history matching of deep coalbed methane considering multiple effects
Youqicang pingjia yu kaifaDeep coal seams are characterized by geological conditions of high in-situ stress, high reservoir temperature, low permeability, and complex tectonic features, resulting in significant differences in gas occurrence states and migration mechanisms ...
SUN XIONGWEI +4 more
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
History Matching the REEK Model
Abstract This chapter presents a simple but realistic history-matching case for a model of reservoir named REEK that we use to illustrate the crucial properties of the history-matching problem when conditioning on production rates.
Geir Evensen +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
History matching of a complex epidemiological model of human immunodeficiency virus transmission by using variance emulation. [PDF]
J R Stat Soc Ser C Appl Stat, 2017 Andrianakis I +7 more
europepmc +1 more source
On the uniqueness of probability matching priors [PDF]
, 2007 Probability matching priors are priors for which Bayesian and frequentist inference, in the form of posterior quantiles, or confidence intervals, agree to some order of approximation.
Staicu, A-M, Reid, N, Reid, Nancy
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source