Results 131 to 140 of about 238,160 (305)

Seismic history matching using proxy models [PDF]

, 2018
Generally, reservoir simulation is used to predict field performance and analyse uncertainties for assistance in decision making, while history matching is a key step in reservoir simulation, which is a process of model adjustment and simulation runs ...
Geng, Chong
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Geostatistically consistent history matching of reservoir flow model using a commercial simulator

Актуальные проблемы нефти и газа
Background. The paper examines the possibility and features of implementing the geostatistically consistent history matching of a reservoir model using reservoir flow simulation software.
Ekaterina O. Elistratova, Ilya M. Indrupskiy   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

History matching by interacting MCMC

, 2009
The history matching problem in reservoir engineering, which consists in matching the geostatistical model to production data, is an ill-posed inverse problem.
Romary, Thomas
core  

An Ensemble Smoother for assisted History Matching

, 2011
This paper compares two ensemble-based data-assimilation methods when solving the history-matching problem in reservoir-simulation models. The methods are the Ensemble Kalman Filter (EnKF) and the Ensemble Smoother (ES).
J.. Hove, G.. Evensen, J.-A.. -A. Skjervheim, J. G. Vabø   +3 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Technology Focus: History Matching and Forecasting (April 2017)

, 2017
Technology Focus The initial work on computer techniques for assisted history matching date back to the 1960s. However, it was a long journey between the development of early methods and operational use.
Alexandre Emerick
core   +1 more source

Automatic history matching of reservoirs based on dual input-output convolutional neural network agent model

Youqi dizhi yu caishoulu
The conventional reservoir automatic history matching method requires multiple computationally time-consuming reservoir numerical simulations. Deep learning agent models can perform alternative reservoir numerical simulation calculations with approximate
CHEN Xu, ZHANG Kai, LIU Chen, ZHANG Jinding, ZHANG Liming, YAO Jun   +5 more
doaj   +1 more source