Results 111 to 120 of about 238,160 (305)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Employment status mobility from a life-cycle perspective [PDF]
In this paper we apply optimal matching techniques to individual work-histories in the British Household Panel Survey (BHPS), with a two-fold objective. First, to explore the usefulness of this sequence-oriented approach to analyze work-histories. Second,
Miguel A. Malo, Fernando Muñoz-Bullón
core
Fairness, Price Stickiness, and History Dependence in Decentralized Trade [PDF]
The paper investigates price formation in a decentralized market with random matching. Agents are assumed to have subdued social preferences: buyers, for example, prefer a lower price to a higher one but experience reduced utility increases below a ...
Stefan Napel, Christian Korth
core +2 more sources
This open-access book aims to formulate the history-matching problem consistently and present state-of-the-art ensemble solution methods. The content aims to help practitioners in the field understand the properties of ensemble methods better when used to history-match reservoir models.
Evensen, Geir +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Using crosswell data to enhance history matching
, 2014 One of the most challenging tasks in the oil industry is the production of reliable reservoir forecast models. Due to different sources of uncertainties in the numerical models and inputs, reservoir simulations are often only crude approximations of the ...
Fabio Ravanelli +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Credible Group Stability in Multi-Partner Matching Problems [PDF]
It is known that in two-sided many-to-many matching markets, pair-wise stability is not logically related with the (weak) core, unlike in many-to-one matching markets (Blair, 1988).
Hideo Konishi, M. Utku Ünver
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Social Games: Matching and the Play of Finitely Repeated Games [PDF]
We examine a new class of games, which we call social games, where players not only choose strategies but also choose with whom they play. A group of players who are dissatisfied with the play of their current partners can join together and play a new ...
Matthew O. Jackson, Alison Watts
core