Results 101 to 110 of about 8,633,749 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A multiobjective dominance and decomposition algorithm for reservoir model history matching

Petroleum, 2019
Reservoir model history matching is a multiobjective optimization problem. It involves the adjustment of relevant reservoir model input parameters, to minimize the mismatch between simulated and observed reservoir responses and to obtain a diverse set of
Osho Ilamah
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Prior Aperture Realizations From Far‐Field Stress Approximation for Ensemble‐Based Data Assimilation in Naturally Fractured Reservoirs

Water Resources Research
Fractures are ubiquitous in reservoirs used for geothermal heat extraction, CO2 storage, and other subsurface applications. Their significant impact on flow and transport requires accurate characterization for performance estimation and risk assessment ...
Michael Liem, Giulia Conti, Stephan Matthai, Patrick Jenny   +3 more
doaj   +1 more source

Synergizing Machine Learning and Physical Models for Enhanced Gas Production Forecasting: A Comparative Study of Short- and Long-Term Feasibility

Energies
Advanced strategies for production forecasting, operational optimization, and decision-making enhancement have been employed through reservoir management and machine learning (ML) techniques.
Bafren K. Raoof, Ali Rabia, Usama Alameedy, Pshtiwan Shakor, Moses Karakouzian   +4 more
doaj   +1 more source

Ohio Historical Society Communication Exhibit photograph

, 1970
This photograph documents visitors to the Ohio Historical Society's exhibit on communication. The exhibit was one of the first to open in the new Ohio History Center in 1970. The photograph measures 9.5" x 7.5" (24.13 x 19.05 cm). Founded in 1885, the
Ohio History Connection
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Boosting Reservoir Prediction Accuracy: A Hybrid Methodology Combining Traditional Reservoir Simulation and Modern Machine Learning Approaches

Energies
This study presents a comprehensive investigation into the application of reservoir simulation and machine learning techniques to improve the understanding and prediction of reservoir behavior, focusing on the Sarir C-Main field.
Mohammed Otmane, Syed Imtiaz, Adel M. Jaluta, Amer Aborig   +3 more
doaj   +1 more source

Multivariate and Propensity Score Matching Software with Automated Balance Optimization: The Matching package for R [PDF]

Matching is an R package which provides functions for multivariate and propensity score matching and for finding optimal covariate balance based on a genetic search algorithm.
Jasjeet S. Sekhon
core