Results 91 to 100 of about 238,160 (305)

Calibration of Cohorts of Virtual Patient Heart Models Using Bayesian History Matching. [PDF]

open access: yesAnn Biomed Eng, 2023
Rodero C   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Assisted history matching using pattern recognition technology

open access: yes, 2014
Reservoir simulation and modeling is utilized throughout field development in different capacities. Sensitivity analysis, history matching, operations optimization and uncertainty assessment are the conventional analyses in full field model studies ...
Shahkarami, Alireza
core   +1 more source

History matching of experimental and CMG-STARS results

open access: yesJournal of Petroleum Exploration and Production Technology, 2018
At present, chemical flooding is one of essential enhanced oil recovery methods. In this study, three core flooding experiments (brine flooding, Alkaline, and Alkaline + Ionic Liquid slug flooding) were selected for history matching using CMG-STARS ...
Ahmed Tunnish, Ezeddin Shirif, Amr Henni
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Principal-Agent Matching Market [PDF]

open access: yes
We propose a model based on competitive markets in order to analyse an economy with several principals and agents. We model the principal-agent economy as a two-sided matching game and characterise the set of stable outcomes of this principal-agent ...
Kaniska Dam
core  

Many-objective optimization algorithm applied to history matching

open access: yes, 2017
Reservoir model calibration, called history matching in the petroleum industry, is an important task to make more accurate predictions for better reservoir management.
Hutahaean, Junko Jhonson Juntianus   +2 more
core   +1 more source

A machine learning framework for rapid forecasting and history matching in unconventional reservoirs. [PDF]

open access: yesSci Rep, 2021
Srinivasan S   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Seismic history matching uncertainty with weighted objective functions

open access: yes, 2018
History matching using 4D seismic time-lapse data provide a method to manage uncertainties of multi-models, but it remains a great challenge without reaching any clear statements or practical methodology or good practise to follow.
MacBeth, Colin   +5 more
core   +1 more source

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