Results 101 to 110 of about 196,484 (310)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Central European History and the Opening up of Europe [PDF]

Contemporary European History, 2018
Since its creation in 1992 the journal Contemporary European History (CEH) has actively sought to bridge Cold War divides and to bring the histories of Eastern, Western, Northern and Southern Europe into the same frame of analysis. In the journal's twenty-five-year history there has probably been no single institution that has played as significant a ...
openaire   +1 more source

Into the Void: Governing Finance in Central and Eastern Europe [PDF]

Twenty years after the fall of the iron curtain-which for decades had separated East from West-most countries of Central and Eastern Europe are now members of the European Union; some have even adopted the euro.
Pistor, Katharina
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Poland and the Silesians : Minority rights à la carte?

, 2012
The Silesians are an ethnic or national group that coalesced in the nineteenth century. During the subsequent century, they survived repeated divisions of their historical region of Upper Silesia among the nation-states of Czechoslovakia (or today its ...
Kamusella, Tomasz Dominik
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

‘Archetypal Load of Tension’: Idiosyncratic Idioms of Surrealism Created by Aleksander Krzywobłocki and Margit Reich-Sielska in the 1930s in Lviv

Arts
This article examines the artistic contributions of two members of the ‘artes’ group, active in Lviv (Lwów during the interwar period) from 1929 to 1935: Aleksander Krzywobłocki (1901–1979) and Margit Reich-Sielska (1900–1980). Situated within the ‘artes’
Irena Kossowska
doaj   +1 more source

An Exploration of Oral History in Central and Eastern Europe

Bulletin de l’AFAS, 2022
Cet article aborde l’histoire orale hongroise non pas du côté de l’historiographie mais plutôt de celui de la méthode mise en œuvre dans les collectes de témoignage, et son évolution des années 1980 à nos jours. Il aborde cette question de l’utilisation des sources orales en Hongrie à partir de la période socialiste et jusqu’à aujourd’hui à travers le ...
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

L’urbanisme et l’architecture des villes d’Europe centrale pendant la première moitié du xxe siècle

Perspective, 2008
Early 20th-century Central Europe is a territory defined, not by national borders, but by an intricately interwoven network of transnational metropoles – of modernizing cities – that were the principal arenas of public culture in the Habsburg Empire and ...
Eve Blau
doaj   +1 more source