Results 81 to 90 of about 1,652,481 (345)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Polish–Lithuanian Commonwealth as a Border Experience of the City

Acta Universitatis Sapientiae: European and Regional Studies, 2019
Referring to Fustel de Coulanges’ distinction of urbs and civitas, the article discusses political theory and practice in 16th-17th-century Poland. While in western Europe an important shift in the notion of politics took place, and the civitas aspect of
Barwicka-Tylek Iwona
doaj   +1 more source

GEOGRAPHY, ASSIMILATION, AND DIALOGUE: Universalism and Particularism in Central-European Thought [PDF]

There are many advantages and disadvantages to central locations. These have shown themselves in the long course of European history. In times of peace, there are important economic and cultural advantages (to illustrate: the present area of the Czech ...
Callaway, H. G.
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Delimiting Central Europe as a Juridical Space: A Preliminary Exercise in Critical Legal Geography

Acta Universitatis Lodziensis Folia Iuridica, 2019
The aim of the present paper is to contribute to the on-going discussion, both in legal theory and in comparative law, concerning the status of Central Europe and its delimitation from other legal regions in Europe, notably Romano-Germanic Western Europe
Rafał Mańko
doaj   +1 more source

Patterns in species richness and endemismof European freshwater fish [PDF]

, 2007
Aim To analyse the patterns in species richness and endemism of the native European riverine fish fauna, in the light of the Messinian salinity crisis and the Last Glacial Maximum (LGM). Location European continent.
Bernard Hugueny, BIANCO, PIER GIORGIO, Didier Pont, Yorick Reyjol   +3 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Disregarded epistemologies in education? Critical approaches toSociologies and Histories of Education in Central and Eastern Europe:Introduction to the Special Issue [PDF]

Revista de Știinţe Educaţiei
This special issue takes stock of current developments in the critical study of sociologies andhistories of education in the Central and Eastern European region.
Elena UNGUREANU, Leyla SAFTA-ZECHERIA, Octavia BORȘ-GEORGESCU   +2 more
doaj   +1 more source

Central European History and the Opening up of Europe [PDF]

Contemporary European History, 2018
Since its creation in 1992 the journal Contemporary European History (CEH) has actively sought to bridge Cold War divides and to bring the histories of Eastern, Western, Northern and Southern Europe into the same frame of analysis. In the journal's twenty-five-year history there has probably been no single institution that has played as significant a ...
openaire   +1 more source