Results 81 to 90 of about 196,484 (310)

Chernozem. From concept to classification: a review

Acta Universitatis Carolinae Geographica, 2016
In this paper, we put together the most important facts that lead to the research on chernozem. Thanks to the work of V. V. Dokuchaev (1846–1903), chernozem stands at the forefront of pedology. In 1883, Dokuchaev introduced the first concept of chernozem:
Barbora Vysloužilová, Damien Ertlen, Dominique Schwartz, Luděk Šefrna   +3 more
doaj   +1 more source

"Great expectations - The regional administrative reform in Eastern Central Europe in anticipation of the EU" [PDF]

, 2000
[Introduction]. One of the key issues of governance of European Union is relationship between its governance and its boundaries in broad sense adopted by Friis and Murphy, who distinguish (after Smith 1996) four types of EU boundary; geopolitical ...
Majcherkiewicz, Tatiana.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Polish–Lithuanian Commonwealth as a Border Experience of the City

Acta Universitatis Sapientiae: European and Regional Studies, 2019
Referring to Fustel de Coulanges’ distinction of urbs and civitas, the article discusses political theory and practice in 16th-17th-century Poland. While in western Europe an important shift in the notion of politics took place, and the civitas aspect of
Barwicka-Tylek Iwona
doaj   +1 more source

Delimiting Central Europe as a Juridical Space: A Preliminary Exercise in Critical Legal Geography

Acta Universitatis Lodziensis Folia Iuridica, 2019
The aim of the present paper is to contribute to the on-going discussion, both in legal theory and in comparative law, concerning the status of Central Europe and its delimitation from other legal regions in Europe, notably Romano-Germanic Western Europe
Rafał Mańko
doaj   +1 more source

Central Banks as Agents of Economic Development [PDF]

In the last two decades, there has been a global sea change in the theory and practice of central banking. The currently dominant “best practice” approach to central banking consists of the following: (1) central bank independence (2) a focus on ...
Gerald Epstein
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Disregarded epistemologies in education? Critical approaches toSociologies and Histories of Education in Central and Eastern Europe:Introduction to the Special Issue [PDF]

Revista de Știinţe Educaţiei
This special issue takes stock of current developments in the critical study of sociologies andhistories of education in the Central and Eastern European region.
Elena UNGUREANU, Leyla SAFTA-ZECHERIA, Octavia BORȘ-GEORGESCU   +2 more
doaj   +1 more source